Fly Brain HubFlyEM Optic Lobe Connectome
HHMI Janelia FlyEM Project Team with Google Connectomics
Complete wiring diagram of the right optic lobe of an adult male fruit fly, the visual-processing region, produced by Janelia's FlyEM team with Google's connectomics group. It catalogs more than 50,000 neurons in over 700 types, including roughly 16,000 intrinsic and 32,000 connecting neurons, and is served on neuPrint as optic-lobe v1.1 after a 2024 data release. The accompanying paper, a connectome-driven inventory of a complete visual system, was published in Nature in 2025.
Sources checked
Every fact above was read from these pages on the date the entry was added.
- janelia.org https://www.janelia.org/project-team/flyem/optic-lobe
- janelia.org https://www.janelia.org/project-team/flyem
Used by: 5 projects
Insectome (Bug Connectome Project)
theworker02
A local studio over several insect connectome packs — neuPrint hemibrain, MANC and optic lobe, plus Insect Brain Database projectomes — browsed by silhouette and cell class rather than by lists of IDs. It reuses published level-0 and level-1 graphs instead of re-segmenting electron microscopy, keeps raw EM remote, and holds the local cache to a 10 GB ceiling; the shareable Pages build ships about 23 MB of catalogs against a 1.7 GB local pack footprint. Its stated rules include never merging the packs into an invented single insectome and never claiming synaptic connectivity without evidence.
Male visual system connectome analysis
reiserlab
Analysis code supporting Nern and colleagues’ 2025 study of the male Drosophila visual-system connectome. It provides a reproducible entry point into the study’s computations and figures, complementing the interactive Cell Type Explorer. This is the associated research-code resource, rather than an additional connectome dataset.
VFB Self-Led Learning (NeuroFly 2026)
Virtual Fly Brain team
Virtual Fly Brain reopened the hands-on workshop it built for NeuroFly 2026 as seven self-led sessions anyone can work through for free, announced on the VFB news page on 6 September 2026. They run from finding a neuron, through bridging between datasets, to pulling in single-cell transcriptomics, and each can be done five ways: the vfb_connect Python client, natverse in R via reticulate, a natural-language chat, an MCP endpoint for driving it from an LLM, or the 3D browser. Material covers BANC, male CNS, MANC and the optic lobe. The footer states GPL v2.
coconatfly
Gregory Jefferis (natverse)
An R package from Greg Jefferis that puts one uniform interface over the major fly connectomes so the same partner-query or cell-type comparison can be run across hemibrain, FlyWire, MANC, FANC, BANC, the male CNS and the male optic lobe. It is flagged as experimental and its API may still change, but it is already the workhorse for hemibrain-versus-FlyWire comparisons in the natverse community.
FlyWire Codex
Princeton Neuroscience Institute
A browser-based explorer developed at the Princeton Neuroscience Institute that lets anyone search, filter and visualise large connectomes entirely in the browser, with no local install or bulk download. Beyond FlyWire's own FAFB v783 (139,255 neurons) it now serves BANC v888, Janelia's MANC v1.2.1, the male optic lobe (MAOL v1.1) and the male CNS v1.0, and had passed 60,000 registered users by early 2026. The open-source code lives in the murthylab/codex repository under Apache-2.0.