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fly-protein

Srikar Jy (@srikarjy)

Asks whether a mushroom-body sparse code, built on real projection-neuron to Kenyon-cell edges from the hemibrain, can find high-fitness protein variants on a small measurement budget, and answers no. Across 10 ProteinGym assays and 20 seeds at matched budgets, the fly learner reaches the top 1 percent in 30.5 percent of runs at 50 measurements against 54.5 for an evolutionary search and 40.0 for plain random search. An ablation finds real hemibrain wiring slightly worse than random wiring.

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fly-protein

#protein-engineering#proteingym#flyhash#mushroom-body#benchmark#negative-result#hemibrain

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