Drosophila MaleCNS Perturbomics

An R pipeline that perturbs every annotated cell-type unit of the MaleCNS connectome once and summarises its downstream reach across effector channels with a linear propagation model over synapse counts normalised by input. Four hypotheses are stated before the run: whether the perturbome is low-dimensional, where types sit on a specialist-generalist axis, whether anatomically distinct types produce similar effects, and whether published descending-neuron phenotypes agree with predicted similarity. The model is deliberately unsigned because transmitter sign is not reliable for all classes.

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#perturbation#analysis-pipeline#preregistered#r#null-models#malecns