Wired Different (ConnectomeLens)

Trains a gradient-boosted classifier on the male-only MaleCNS v1.0 cell-type graph (11,751 types, 243,439 edges) to predict Janelia's male-specific and dimorphic labels, then asks whether the real wiring beats 500 degree-preserving rewirings. All features give AUC-PR 0.759 against 0.712 for the nulls; the sharper test is topology alone, 0.489 against 0.070, at p = 0.002. The repo writes down what it may and may never assert, calls its two flagged types candidates rather than findings, and publishes a pre-specified check that failed. The site adds an atlas, a pathfinder and a guessing game.

Official site ↗Repository ↗

#machine-learning#sexual-dimorphism#cell-types#null-model#malecns