Etanol y comportamiento en una Drosophila in silico

A simulated fly in an arena whose behaviour comes from 20,000 MaleCNS v1.0 neurons and 1,319,744 signed connections, with nothing scripted: feeding fires when the proboscis motor neuron MN9 does, escape when the giant fibre crosses threshold, posture from leg motor neuron tone. Ethanol acts only on synaptic transmission, and hyperactivity, loss of leg tone, falls and loss of the righting reflex come out of that. A degree-preserving shuffled wiring is the control: odour-guided feeding drops from 97.5% to 0% and bitter rejection from 100% to 0%, while escape and sugar acceptance survive it.

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#ethanol#mushroom-body#shuffled-control#foraging#malecns#spanish