Fly Brain HubBH26: MaleCNS sniffs cells
Jiandong Chen, Masao Nagasaki (Kyushu University)
A BioHackathon Japan 2026 project report asking whether a fly brain can do useful work on genomics data. The mushroom body turns an odour into a sparse code over Kenyon cells, and its alpha-prime-3 compartment behaves as a novelty detector whose output neurons are suppressed by dopamine within a few repetitions of the same odour. The project presents single-cell RNA-seq profiles to the simulated brain as odours and reads that compartment's output as a novelty score, so cells resembling ones already smelled habituate. Reported in three stages, from blood cells to a lung adenocarcinoma dataset.
Sources checked
Every fact above was read from these pages on the date the entry was added.
- raw.githubusercontent.com https://raw.githubusercontent.com/biohackathon-japan/BH26-MaleCNS-sniffs-cells/HEAD/paper/paper.md
- github.com https://github.com/biohackathon-japan/BH26-MaleCNS-sniffs-cells