Fly Brain HubBottlenecks of the Fly Brain
danilo-lazovic
Max-flow / min-cut analysis of the male CNS wiring, asking which neurons sit between a sense and the descending neurons that drive movement. Cutting to all 1,314 descending neurons says nothing: the cut is just the first relay layer, because the CNS is shallow, a median of two hops from any sense. Restricted to a single target it becomes informative, and the vision-to-giant-fiber cut is dominated by LPLC2 and LC4, known experimentally to drive looming escape. Removing those neurons leaves 83% of synapse flow against 99.99% for random on-path controls. The spiking ablation step is unfinished.
Sources checked
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- raw.githubusercontent.com https://raw.githubusercontent.com/danilo-lazovic/fly-bottlenecks/HEAD/README.md