brainfly

An attempt to close the loop from the MaleCNS connectome to a walking body, labelling every layer as validated, fitted or guessed. Each rung must match real-fly data and stop working when the wiring is scrambled. Tiling a fitted optic-lobe network onto the male eye gives correct direction preferences for all 16 T4/T5 types and a giant-fibre escape spike to looming; HS cells and DNa02 follow a rotating drum and eight NeuroMechFly flies turn with it, while three random rewirings abolish the signal. The whole-brain rung has failed five times and the fifth network still fails one of its two nulls.

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#malecns#null-control#pre-registered#optomotor#neuromechfly#negative-results